Tesco is set to close its Brackmills beers, wines and spirits depot in Northamptonshire in May.
The 15-year-old depot can no longer cope with demand and is to be converted into a Tesco.com depot, subject to consultation with trade unions, said Tesco.
"We will support all affected staff through the difficult period ahead and will do as much as possible to find them an alternative role in Tesco for those who want it," said a Tesco spokesman.
Usdaw divisional officer Gary Holz described the news as devastating and said the union would use the 90-day consultation period to look at the business plan behind the decision.
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